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Published by Elsevier Ltd. Export Reference Manager BibTeX EP3 XML Dublin Core HTML Citation ASCII Citation EndNote. Sie sind hier: Start Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy PARTNER : final of a multicentre, prospective, observational study.
During eligible couple-years of follow-up, couples reported condomless anal sex a total of 76 times. Findings Between Sept 15,and July 31,gay couples were enrolled, of which provided eligible couple-years of follow-up with a median follow-up of 2.
Creators ORCID ORCID Put Code Rodger, Alison J. Copyright C The Author s. Lancet, NEW YORK: ELSEVIER SCIENCE INC. ISSN X. Background The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy ART is limited compared with the evidence available for transmission risk in heterosexual couples.
Methods The PARTNER study was a prospective observational study done at 75 sites in 14 European countries. Interpretation Our provide a similar level of evidence on viral suppression and HIV transmission risk for gay men to that ly generated for heterosexual couples and suggest that the risk of HIV transmission in gay couples through condomless sex when HIV viral load is suppressed is effectively zero. Rodger, Alison J. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy PARTNER : final of a multicentre, prospective, observational study.
At study visits, data collection included sexual behaviour questionnaires, HIV testing HIV-negative partnerand HIV-1 viral load testing HIV-positive partner. DOI: Downlo Downlo per month over past year.
Incidence rate of HIV transmission was calculated as the of phylogenetically linked HIV infections that occurred during eligible couple-years of follow-up divided by eligible couple-years of follow-up. If a seroconversion occurred in the HIV-negative partner, anonymised phylogenetic analysis was done to compare HIV-1 pol and env sequences in both partners to identify linked transmissions. The aim of the second phase of the PARTNER study PARTNER2 was to provide precise estimates of transmission risk in gay serodifferent partnerships.
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The first phase of the study PARTNER1; Sept 15,to May 31, recruited and followed up both heterosexual and gay serodifferent couples HIV-positive partner taking suppressive ART who reported condomless sex, whereas the PARTNER2 extension to April 30, recruited and followed up gay couples only. ISSN X Full text not available from this repository.
At baseline, median age for HIV-positive partners was 40 years IQR and couples reported condomless sex for a median of 1.